T. Honda

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants

This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.

Circulating mast cell progenitors migrate to atopic dermatitis-like skin then adapt locally

The paper identifies BM-derived mast cell progenitors in AD-like skin that adapt to CTMC phenotypes through local proliferation and integrinβ7 downregulation.

The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, are potent BACH1 inhibitors

This study identifies CDDO-derivatives as BACH1 inhibitors, explaining their higher potency as HMOX1 inducers compared to CDDO.

Coordination of gene expression with cell size enables Escherichia coli to efficiently maintain motility across conditions

This study shows E. coli upregulates motility genes at slow growth to maintain flagella number and motility, while larger cell size at fast growth optimizes resource allocation.

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity.

This study uses Hmox1 reporter mice to demonstrate iAs-induced oxidative stress and validate N-acetyl cysteine as a potential therapy for arsenic toxicity.

Aberrant claudin-6-adhesion signal promotes endometrial cancer progression via estrogen receptor α

The paper shows that CLDN6 promotes endometrial cancer progression by activating estrogen receptor α through SFK/PI3K signaling, independent of ligand.

The kinase inhibitor AT9283 selectively kills colorectal cancer cells with hyperactive NRF2

The paper identifies AT9283 as a drug that selectively kills colorectal cancer cells with hyperactive NRF2, showing its potential as a therapeutic target.