Author

C. R. Wolf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Microbiology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

C. J. Henderson· 3 shared H. Y. Chu· 3 shared C. I. Stoddard· 2 shared F. A. Matsen· 2 shared H. L. Itell· 2 shared J. Galloway· 2 shared J. K. Logue· 2 shared M. A. J. Chaplain· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

C. J. Henderson

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Author profile →

7 papers

Recent·Most cited

Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies

A. De Carli, Y. Kapelyukh, J. Kursawe, M. A. J. Chaplain, C. R. Wolf, S. J. HAMIS

This paper develops a mathematical model of BRAFV600E-MEK-ERK signaling dynamics to simulate responses to vertical inhibition treatment strategies and identify effective combinations.

bioRxiv · Dec 12, 2023Cancer Biology

Quantifying ERK-activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling

S. Hamis, Y. Kapelyukh, A. McLaren, C. J. Henderson, C. R. Wolf, M. A. J. Chaplain

This study develops a mathematical model to quantify how dabrafenib and trametinib inhibit ERK-activity in BRAFV600E-mutant melanoma cells and identify mechanisms of drug resistance.

bioRxiv · Apr 20, 2021Cancer Biology

High resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies

M. E. Garrett, J. Galloway, H. Y. Chu, H. L. Itell, C. I. Stoddard, C. R. Wolf, J. K. Logue, D. McDonald, F. A. Matsen, J. Overbaugh

This study identifies antibody escape pathways for SARS-CoV-2 spike protein using Phage-DMS, revealing variable escape mutations in immunodominant regions and individual epitope targeting differences.

bioRxiv · Nov 16, 2020Immunology

Epitope profiling reveals binding signatures of SARS-CoV-2 immune response and cross-reactivity with endemic HCoVs

C. I. Stoddard, J. Galloway, H. Y. Chu, M. M. Shipley, H. L. Itell, C. R. Wolf, J. K. Logue, A. Magedson, K. Sung, M. Garrett, K. H. Crawford, U. Laserson, F. A. Matsen, Julie Overbaugh

This study maps SARS-CoV-2 antibody epitopes and identifies cross-reactive sequences with endemic HCoVs in COVID-19 patients.

bioRxiv · Oct 29, 2020 · PreprintImmunology

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity.

F. Inesta-Vaquera, P. Navasumrit, C. J. Henderson, T. G. Frangova, T. Honda, A. T. Dinkova-Kostova, M. Ruchirawat, C. R. Wolf

This study uses Hmox1 reporter mice to demonstrate iAs-induced oxidative stress and validate N-acetyl cysteine as a potential therapy for arsenic toxicity.

bioRxiv · Jun 19, 2020Pharmacology & Toxicology

Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein for neutralization assays

K. H. D. Crawford, R. Eguia, A. S. Dingens, A. N. Loes, K. D. Malone, C. R. Wolf, H. Y. Chu, M. A. Tortorici, D. Veesler, M. Murphy, D. Pettie, N. P. King, A. B. Balazs, J. D. Bloom

This paper provides a protocol for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein to measure neutralizing antibody activity in a luciferase-based assay.

bioRxiv · Apr 20, 2020Microbiology

Measuring physiological responses to stressors using a novel Hmox1 reporter mouse

M. McMahon, S. Ding, L. P. Acosta-Jimenez, T. G. Frangova, C. J. Henderson, C. R. Wolf

This paper develops a novel Hmox1 reporter mouse to measure physiological responses to stressors, showing it accurately reflects oxidative and inflammatory stimuli.

bioRxiv · Jan 5, 2017Physiology