P. Chakraborty

p23-FKBP51 chaperone complex regulates tau aggregation

This study identifies the p23-FKBP51 chaperone complex as an Hsp90-independent regulator of tau aggregation, showing it forms a trimeric complex that inhibits tau fibril formation.

GSK3β phosphorylation catalyzes the aggregation of Tau into Alzheimer's disease-like amyloid strain

This study shows GSK3β phosphorylation drives tau aggregation into Alzheimer's-like amyloid strains through enhanced phase separation.

Cell-autonomous BMP signalling plays a key role in the maintenance of tumour cell EMT and migration programs in human ovarian carcinoma

This study investigates the role of BMP signaling in maintaining EMT and migration in ovarian cancer cells, showing that inhibiting BMP reduces EMT and migration.

Spatio-temporal Pattern Formation due to Host-Circuit Interplay in Gene Expression Dynamics

The paper investigates spatio-temporal pattern formation in a cellular array with non-cooperative positive feedback, analyzing stability and spatial distribution under varying diffusion conditions.

Activation of ERK by altered RNA splicing in cancer

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

Immunodominant influenza epitope GILGFVFTL engage common and divergent TCRs when presented as a 9-mer or a 15-mer peptide

The paper compares T-cell engagement with a 9-mer and 15-mer version of the GILGFVFTL epitope to assess differences in TCR diversity and activation kinetics.

Regulation of Store-Operated Ca2+ Entry by IP3 Receptors Independent of Their Ability to Release Ca2+

The paper shows IP3Rs regulate neuronal SOCE through IP3 binding, independent of Ca2+ release, by enhancing STIM1-Orai1 association.

P4HA2: A link between tumor-intrinsic hypoxia, partial EMT and collective migration

This study identifies P4HA2 as a central regulator linking tumor-intrinsic hypoxia, partial EMT, and collective migration using microtumor models and differential gene expression analysis.

Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

This study identifies age-associated functional subpopulations of skeletal muscle macrophages using single-cell transcriptomics in mice.

Spontaneous differentiation leads to emergence of hybrid cell states relate to poor prognosis in oral cancer

This study identifies dynamic phenotypic states in oral cancer cells and their association with poor prognosis through transcriptomic heterogeneity and drug tolerance.

Epithelial-mesenchymal plasticity through loss of CTCF motif accessibility and protein expression

The paper investigates chromatin accessibility and CTCF dynamics during reversible EMT/MET, showing CTCF suppression correlates with EMT features and plasticity.

Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum

The paper analyzes immune subtypes across the epithelial-mesenchymal plasticity spectrum in cancers, finding heterogeneity in EMT status and associations between immune subtypes and EMT scores.

Dynamic plasticity within the EMT spectrum, rather than static mesenchymal traits, drives tumor heterogeneity and metastatic progression of breast cancers

This study identifies intermediate EMT states in breast cancer and develops a model to quantify their role in tumor heterogeneity and metastasis.

A theoretical approach to coupling the epithelial-mesenchymal transition (EMT) to extracellular matrix (ECM) stiffness via LOXL2

The paper introduces a computational model linking LOXL2 secretion to ECM stiffness and ZEB1 levels, showing a positive feedback loop that locks cells in a mesenchymal state during EMT.

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

This study identifies immunodominant T-cell epitopes in SARS-CoV-2 spike antigen and shows pre-existing T-cell immunity in unexposed individuals, suggesting prior exposure to common viruses like Influenza and CMV.

Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum

The paper evaluates gene expression signatures for inflammatory breast cancer (IBC) across multiple datasets, finding low overlap and limited predictive accuracy, but identifying a correlation between IBC samples and the epithelial-hybrid-mesenchymal spectrum.

Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT

This study identifies two mechanisms—epigenetic feedback in the ZEB1/GRHL2 loop and stochastic partitioning during cell division—that can drive resistance to EMT in cancer cells.

Gene expression and chromatin accessibility during progressive EMT and MET linked to dynamic CTCF engagement

The paper examines gene expression and chromatin accessibility changes during reversible EMT and MET in mammary epithelial cells, highlighting CTCF's role in chromatin reorganization and stemness.

Comparative study of transcriptomics-based scoring metrics for the epithelial-hybrid-mesenchymal spectrum

This study compares three transcriptomics-based metrics for quantifying EMT status across tumor types, finding that MLR-based scoring better distinguishes pure hybrid E/M cells from mixed populations.

DHX9-dependent recruitment of BRCA1 to RNA is required to promote DNA end resection in homologous recombination

This study shows DHX9 is essential for BRCA1 recruitment to DNA damage via RNA binding, which promotes DNA end resection in homologous recombination.