LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 Transactivation
K. C. Klatt, S. Zhang, O. V. Malysheva, Z. Sun, B. Dong, J. T. Brenna, D. D. Moore, M. S. Roberson, M. A. Caudill
This study shows that lauric acid intake leads to endogenous production of DLPC, an LRH-1 ligand, and enhances LRH-1 transcriptional activity in multiple tissues.
bioRxiv · Feb 1, 2021 · PreprintPhysiology