Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine
F. Chiuppesi, M. S. Werner, H. Contreras, H. V. Nguyen, J. Martinez, S. Park, J. Nguyen, M. Kha, A. Iniguez, Q. Zhou, T. Kaltcheva, R. Levytskyy, N. D. Ebelt, T. H. Kang, X. Wu, , F. Wussow
This paper develops a synthetic DNA-based vaccine platform to rapidly generate SARS-CoV-2 vaccines using recombinant MVA vectors expressing spike and nucleocapsid antigens, showing robust immune responses in mice.
bioRxiv · Jul 1, 2020 · PreprintImmunology