Author

E. R. Manuel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

N. D. Ebelt· 2 shared R. Salgia· 2 shared A. Bild· 1 shared A. Iniguez· 1 shared A. Kalvala· 1 shared A. Nam· 1 shared A. Nathan· 1 shared B. R. Blazar· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

N. D. Ebelt

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Author profile →

3 papers

Recent·Most cited

Restructuring of the Immune Contexture Improves Checkpoint Blockade Efficacy in Murine Lung Cancer

N. D. Ebelt, E. Zuniga, M. Marzagalli, V. Zamloot, B. R. Blazar, R. Salgia, E. R. Manuel

This study shows that altering the tumor immune landscape with shIDO-ST improves checkpoint blockade efficacy in murine lung cancer by enhancing antigen presentation and reducing suppressive immune cells.

bioRxiv · Oct 9, 2020 · PreprintCancer Biology

Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine

F. Chiuppesi, M. S. Werner, H. Contreras, H. V. Nguyen, J. Martinez, S. Park, J. Nguyen, M. Kha, A. Iniguez, Q. Zhou, T. Kaltcheva, R. Levytskyy, N. D. Ebelt, T. H. Kang, X. Wu, , F. Wussow

This paper develops a synthetic DNA-based vaccine platform to rapidly generate SARS-CoV-2 vaccines using recombinant MVA vectors expressing spike and nucleocapsid antigens, showing robust immune responses in mice.

bioRxiv · Jul 1, 2020 · PreprintImmunology

Phenotypic Switching of Naïve T cells to Immune-suppressive Treg-like Cells by Mutant KRAS

A. Kalvala, P. Wallet, L. Yang, C. Wang, H. Li, A. Nam, A. Nathan, I. Mambetsariev, V. Poroyko, H. Gao, P. Chu, M. Sattler, A. Bild, E. R. Manuel, P. P. Lee, , R. Salgia

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

bioRxiv · Sep 11, 2019Cancer Biology