Quantitative Comparison of Presenilin Protein Expression Reveals Greater Activity of PS2-gamma-Secretase.
M. K. Eccles, N. Main, M. Sabale, B. Roberts-Mok, M. Agostino, D. Groth, P. E. Fraser, G. Verdile
This study quantifies PS1 and PS2 protein expression levels and shows PS2-gamma-secretase has equal or greater activity than PS1-gamma-secretase in APP and Notch1 processing.
bioRxiv · May 9, 2023Cell Biology