A Yersinia effector activates JAK-STAT signaling in human macrophages
L. Berneking, I. Bekere, M. Schnapp, J. Huang, K. Ruckdeschel, M. Aepfelbacher
This study shows YopM activates JAK-STAT signaling in macrophages by promoting Stat3 nuclear translocation, independent of IL-10 or RSK1, thereby increasing IL-10 gene expression.
bioRxiv · May 8, 2023 · PreprintCell Biology