A. Grundhoff

Limited protection against early-life cytomegalovirus infection results from deficiency of cytotoxic CD8T cells

This study shows that deficiency of cytotoxic CD8 T cells in early life leads to limited protection against cytomegalovirus infection.

Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition

This study investigates VZV gene repression in neuronal cells, finding that histone deposition is absent at quiescent viral genomes.

Yersinia remodels epigenetic histone modifications in human macrophages

This study shows Yersinia enterocolitica modulates histone modifications in human macrophages to alter gene expression related to immune response and metabolism.

Human antigen-specific memory natural killer cell responses develop against HIV-1 and influenza virus and are dependent on MHC-E restriction

This study shows human NK cells develop antigen-specific memory against HIV-1 and influenza via MHC-E restriction, validated through single-cell cloning and biomarker analysis.

SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19

The paper investigates SARS-CoV-2 infection in carotid arteries of COVID-19 patients using genomic, virologic, histochemical, and transcriptomic analyses, showing productive infection and vascular modulation.

The landscape of viral associations in human cancers

The paper systematically investigates viral associations in human cancers using whole-genome and transcriptome data from 2,656 donors, revealing prevalence of known tumor-associated viruses and their genomic impacts.

Oncogenic herpesvirus engages the endothelial transcription factors SOX18 and PROX1 to increase viral genome copies and virus production

This study shows that SOX18 and PROX1, endothelial transcription factors, regulate KSHV lytic replication and virus production in lymphatic endothelial cells.

The first days in the life of naïve human B-lymphocytes infected with Epstein-Barr virus

This study identifies EBNA2 as essential for early EBV infection of naive B-cells, showing it drives activation, proliferation, and prevents cell death, while other latent genes have minimal or no effect during the pre-latent phase.

Human cytomegalovirus nuclear capsid motility is non-directed and independent of nuclear actin bundles

This study investigates whether HCMV-induced nuclear actin bundles mediate capsid transport, finding no evidence of directed motility or active transport along nuclear F-actin.

A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment

This study compares the epigenetic features of KSHV and MHV-68, showing that KSHV rapidly recruits polycomb repressive complexes through specific cis-acting sequence features, unlike MHV-68.