M. Aepfelbacher

A Yersinia effector activates JAK-STAT signaling in human macrophages

This study shows YopM activates JAK-STAT signaling in macrophages by promoting Stat3 nuclear translocation, independent of IL-10 or RSK1, thereby increasing IL-10 gene expression.

Live imaging of Yersinia translocon formation and immune recognition in host cells

This study uses live imaging to track the formation, dynamics, and degradation of Yersinia T3SS translocons and their recognition by the immune system in host cells.

Visualization of bacterial type 3 secretion system components down to the molecular level by MINFLUX nanoscopy

The paper uses MINFLUX nanoscopy to visualize T3SS components at high resolution, revealing structural details of bacterial virulence factors.

Yersinia remodels epigenetic histone modifications in human macrophages

This study shows Yersinia enterocolitica modulates histone modifications in human macrophages to alter gene expression related to immune response and metabolism.

C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus

This study develops a C25-modified rifamycin derivative, 5j, which resists enzymatic inactivation by ArrMab and shows potent antimicrobial activity against M. abscessus in vitro and in macrophages.

SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19

The paper investigates SARS-CoV-2 infection in carotid arteries of COVID-19 patients using genomic, virologic, histochemical, and transcriptomic analyses, showing productive infection and vascular modulation.

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis

The paper identifies swiprosin-1 as a cargo-specific adaptor for the CG-pathway, showing its role in integrin internalization and breast cancer progression.

Visualization and regulation of translocons in Yersinia type III protein secretion machines during host cell infection

This study visualizes Yersinia translocons during host infection using superresolution microscopy and shows their regulation by host factors like Rac1.