M. Shmulevitz

Reovirus uses temporospatial compartmentalization to orchestrate core versus outercapsid assembly.

This paper investigates how reovirus assembles its core and outer capsid proteins in distinct spatial and temporal compartments during replication, revealing a spatiotemporal segregation mechanism.

p38 MAPK Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Virus Capsid Uncoating and Post-Uncoating Steps.

This study shows p38 MAPK signaling enhances reovirus replication by improving virus entry, uncoating, and post-uncoating steps, with p38β as a potential prognostic marker for reovirus infection.

Breast tumor-associated metalloproteases restrict reovirus oncolysis by cleaving the σ1 cell-attachment protein, and can be overcome by mutation of σ1

This study shows that breast tumor-associated metalloproteases cleave reovirus σ1 protein, reducing infectivity, and demonstrates that a σ1 mutation can overcome this inactivation.

Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System

This paper generates a recombinant rotavirus with a genetically modified segment 7 dsRNA encoding NSP3-UnaG fusion protein, showing efficient replication and enhanced detection compared to NSP1-based FPs.

Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains

This study identifies genetic polymorphisms in reovirus strains that influence their oncolytic potency by affecting replication and host-cell signaling pathways.