H. E. Eaton

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

Reovirus uses temporospatial compartmentalization to orchestrate core versus outercapsid assembly.

This paper investigates how reovirus assembles its core and outer capsid proteins in distinct spatial and temporal compartments during replication, revealing a spatiotemporal segregation mechanism.

Breast tumor-associated metalloproteases restrict reovirus oncolysis by cleaving the σ1 cell-attachment protein, and can be overcome by mutation of σ1

This study shows that breast tumor-associated metalloproteases cleave reovirus σ1 protein, reducing infectivity, and demonstrates that a σ1 mutation can overcome this inactivation.