A. Mohamed

Endothelial cell dysfunction and retinal arteriolar narrowing in young adults with elevated blood pressure

This study links endothelial cell dysfunction with retinal arteriolar narrowing in young adults with elevated blood pressure, identifying GRB2 as a potential molecular link.

Adenomatous polyposis coli (APC) regulates internalization and signaling of the chemorepellent receptor, Roundabout (ROBO) 1

This study identifies APC's role in SLIT2-induced ROBO1 endocytosis and its impact on cell morphology.

Epitopes- Based Vaccine Design Against Foot and Mouth Disease SAT2 Serotype from Sudanese Isolate by Using Immunoinformatic Approaches

This study designs a multi-epitope peptide vaccine against FMD SAT2 serotype from Sudan using immunoinformatic methods, identifying T-cell and B-cell epitopes with high binding affinity and conservation.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Biosphere functional integrity for people and Planet

The paper estimates the minimum level of functional integrity needed to secure multiple critical Nature's Contributions to People in human-modified landscapes.

p38 MAPK Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Virus Capsid Uncoating and Post-Uncoating Steps.

This study shows p38 MAPK signaling enhances reovirus replication by improving virus entry, uncoating, and post-uncoating steps, with p38β as a potential prognostic marker for reovirus infection.

Molecular profiling of XPO1 inhibitor and gemcitabine-nab-paclitaxel combination in cellular and LSL-Kras G12D/+; Trp53 fl/+; Pdx1-Cre (KPC) pancreatic cancer model

This study investigates the synergy between XPO1 inhibitor selinexor and gemcitabine-nab-paclitaxel in pancreatic cancer using cellular and mouse models, showing improved survival and molecular changes.

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

Sclerostin depletion induces inflammation in the bone marrow of mice

This study shows that sclerostin depletion in mice leads to myeloid-biased hematopoiesis and increased inflammation in the bone marrow.

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.

Hif-1alpha stabilisation is protective against infection in a zebrafish model of co-morbidity

This study shows Hif-1alpha stabilisation protects against tuberculosis infection in zebrafish even when inflammation is present.

Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains

This study identifies genetic polymorphisms in reovirus strains that influence their oncolytic potency by affecting replication and host-cell signaling pathways.

Habitat-Net: Segmentation of habitat images using deep learning

Habitat-Net segments tropical rainforest habitat images using deep learning, achieving higher accuracy and faster processing than manual methods and U-Net.

Shifting up a gear with iDNA: from mammal detection events to standardized surveys

The paper compares iDNA and camera-trap surveys to assess mammal occupancy in tropical rainforests, finding consistent results and suggesting iDNA as a viable complementary method.