Targeting the translational machinery in gastrointestinal stromal tumors (GIST) - a new therapeutic vulnerability
D. M. Lee, A. Sun, S. S. Patil, L. Liu, A. V. Rao, P. T. Trent, A. A. Amir, C. Liu, J. L. Rausch, L. D. Presutti, A. Kaczorowski, F. Schneider, N. Amankulor, M. Shuda, A. Duensing
This study shows that homoharringtonine (HHT) effectively inhibits KIT-dependent GIST growth by reducing protein synthesis, even in imatinib-resistant models.
bioRxiv · Sep 1, 2021Cancer Biology