Author

M. T. Holden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 5 Approach:statistical model· 4 Organism:human· 3 Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:phylogenetics / evolution· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. A. Pettigrew· 2 shared A. Cazares· 1 shared A. J. Roe· 1 shared A. Leanord· 1 shared A. M. Karcher· 1 shared A. M. Kearns· 1 shared A. Moustafa· 1 shared A. Narechania· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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2 shared papersMicrobiology

K. A. Pettigrew

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Author profile →

6 papers

Recent·Most cited

Emergence of optrA-mediated linezolid resistance in multiple lineages and plasmids of Enterococcus faecalis revealed by long read sequencing

M. P. McHugh, B. J. Parcell, K. A. Pettigrew, G. Toner, E. Khatamzas, A. M. Karcher, J. Walker, R. Weir, D. Meunier, K. L. Hopkins, N. Woodford, K. E. Templeton, S. H. Gillespie, M. T. Holden

This study identifies multiple optrA-mediated linezolid resistance variants in Enterococcus faecalis using long-read sequencing, showing genetic diversity and plasmid variability.

Microbiology · Feb 16, 2022Peer-reviewedMicrobiology

The phylogenomic landscape of the genus Serratia

D. J. Williams, P. A. Grimont, A. Cazares, F. Grimont, E. Ageron, K. A. Pettigrew, D. Cazares, E. Njamkepo, F.-X. Weill, E. Heinz, M. T. Holden, N. Thomson, S. J. Coulthurst

This study analyzes 664 Serratia genomes to reveal population structure, ecological niche alignment, and gene flow patterns, highlighting the genus's adaptability and diversity.

bioRxiv · Jan 11, 2022Microbiology

The emergence of successful Streptococcus pyogenes lineages through convergent pathways of capsule loss and recombination directing high toxin expression

C. E. Turner, M. T. Holden, B. Blane, C. Horner, S. J. Peacock, S. Sriskandan

The paper identifies convergent evolutionary pathways in Streptococcus pyogenes lineages through recombination at the nga-slo locus and capsule loss, associated with increased toxin expression and disease success.

mBio · Dec 24, 2019Peer-reviewedMicrobiology

A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage

T. J. Evans, S. Fox, C. Goswami, M. T. Holden, J. P. Connolly, A. J. Roe, M. Connor, A. Leanord

The paper identifies that E. coli ST69 bloodstream isolates contain an intact ETT2 locus, suggesting functional importance in infection despite no identified secreted substrates.

bioRxiv · Aug 21, 2018Microbiology

Mobile genetic element-encoded hypertolerance to copper protects Staphylococcus aureus from killing by host phagocytes

M. Zapotoczna, G. Pelicioli-Riboldi, A. Moustafa, E. Dickson, A. Narechania, J. Morrissey, P. Planet, M. T. Holden, K. Waldron, J. Geoghegan

This study identifies a mobile genetic element encoding copper-hypertolerance genes in S. aureus that enhances survival in host phagocytes.

bioRxiv · Mar 8, 2018Microbiology

Methicillin resistant Staphylococcus aureus emerged long before the introduction of methicillin in to clinical practice

C. P. Harkins, B. Pichon, M. Doumith, J. Parkhill, H. Westh, A. Tomasz, H. de Lencastre, S. D. Bentley, A. M. Kearns, M. T. Holden

This study shows that MRSA emerged in the mid-1940s, long before methicillin was introduced, due to prior use of first-generation beta-lactams.

bioRxiv · Mar 31, 2017Microbiology