Author

D. J. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. A. LeDuc· 2 shared D. Egli· 2 shared R. L. Leibel· 2 shared S. J. Coulthurst· 2 shared A. Cazares· 1 shared B. J. Gonzalez· 1 shared C. A. Doege· 1 shared C. N. Goulbourne· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

C. A. LeDuc

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Author profile →

4 papers

Recent·Most cited

The phylogenomic landscape of the genus Serratia

D. J. Williams, P. A. Grimont, A. Cazares, F. Grimont, E. Ageron, K. A. Pettigrew, D. Cazares, E. Njamkepo, F.-X. Weill, E. Heinz, M. T. Holden, N. Thomson, S. J. Coulthurst

This study analyzes 664 Serratia genomes to reveal population structure, ecological niche alignment, and gene flow patterns, highlighting the genus's adaptability and diversity.

bioRxiv · Jan 11, 2022Microbiology

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

B. J. Gonzalez, H. Zhao, J. Niu, D. J. Williams, J. Lee, C. N. Goulbourne, Y. Xing, Y. Wang, J. Oberholzer, X. Chen, C. A. LeDuc, W. K. Chung, H. M. Colecraft, J. Gromada, Y. Shen, , D. Egli

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

bioRxiv · Jan 26, 2021Cell Biology

Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons

L. Wang, Y. Liu, G. Stratigopoulos, S. Panigrahi, L. Sui, C. A. Leduc, H. J. Glover, M. C. De Rosa, L. C. Burnett, D. J. Williams, L. Shang, R. Goland, S. H. Tsang, S. Wardlaw, D. Egli, , R. L. Leibel

This study investigates how BBS mutations affect neuron function and signaling in iPSC-derived neurons, identifying impaired ciliary function and signaling pathways related to energy homeostasis.

bioRxiv · Oct 29, 2020Cell Biology

A new family of Type VI secretion system-delivered effector proteins displays ion-selective pore-forming activity

G. Mariano, K. Trunk, D. J. Williams, L. Monlezun, H. Strahl, S. J. Pitt, S. J. Coulthurst

The paper identifies Ssp6 as an ion-selective pore-forming toxin delivered by the T6SS of Serratia marcescens, showing it causes membrane depolarization and increased permeability.

bioRxiv · Jun 20, 2019 · PreprintMicrobiology