Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.
N. Li, J. L. Rodriguez, Y. Yin, M. T. Logun, S. Yu, K. A. Hicks, V. Zhang, L. Zhang, C. Xie, J. Wang, J. A. Fraietta, Z. A. Binder, Z. Lin, D. M. O'Rourke
This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.
bioRxiv · Feb 26, 2024Cancer Biology