Author

Z. A. Binder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

D. M. O'Rourke· 5 shared L. Zhang· 3 shared Y. Yin· 3 shared D. Y. Zhang· 2 shared G.-l. Ming· 2 shared H. Song· 2 shared J. V. Zhang· 2 shared M. P. Nasrallah· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersCancer Biology

D. M. O'Rourke

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Brain-wide neuronal circuit connectome of human glioblastoma

Y. Sun, X. Wang, D. Y. Zhang, Z. Zhang, J. P. Bhattarai, Y. Wang, W. Dong, F. Zhang, K. H. Park, J. Galanaugh, A. Sambangi, Q. Yang, S. H. Kim, G. Wheeler, T. Goncalves, , H. Song

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

bioRxiv · Mar 1, 2024Cancer Biology

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

N. Li, J. L. Rodriguez, Y. Yin, M. T. Logun, S. Yu, K. A. Hicks, V. Zhang, L. Zhang, C. Xie, J. Wang, J. A. Fraietta, Z. A. Binder, Z. Lin, D. M. O'Rourke

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

bioRxiv · Feb 26, 2024Cancer Biology

The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and Their Relationship to Oncogenic Drivers

A. Fathi Kazerooni, H. Akbari, X. Hu, V. Bommineni, D. Grigoriadis, E. Toorens, C. Sako, E. Mamourian, D. Ballinger, R. Sussman, A. Singh, I. I. Verginadis, N. Dahmane, C. Koumenis, Z. A. Binder, , C. Davatzikos

This study identifies imaging and spatial biomarkers in glioblastoma that correlate with molecular features and oncogenic drivers using machine learning on MRI data.

bioRxiv · Dec 15, 2022Bioengineering

Locally secreted BiTEs complement CAR T cells by enhancing solid tumor killing

Y. Yin, J. Rodriguez, N. Li, R. Thokala, M. P. Nasrallah, L. Hu, L. Zhang, J. V. Zhang, D. Kainth, L. Haddad, E. X. Johns, Y. Long, H. Liang, J. Qi, X. Zhang, , D. M. O'Rourke

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

bioRxiv · Jun 8, 2021 · PreprintCancer Biology

High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

R. Thokala, Z. A. Binder, Y. Yin, L. Zhang, J. V. Zhang, D. Y. Zhang, M. C. Milone, G.-L. Ming, H. Song, D. M. O'Rourke

This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.

bioRxiv · Feb 4, 2021Cancer Biology

The role of integrin αv and CD44 in GBM migration in human brain

Z. A. Binder, S. H. J. Kim, P.-H. Wu, A. Giri, G. L. Gallia, C. A. Pardo, D. Wirtz

This study uses human organotypic brain slices to examine GBM cell motility, finding that CD44 knockdown reduces motility more than ITGAV knockdown.

bioRxiv · Nov 16, 2019 · PreprintCancer Biology