Author

M. T. McCabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

M. B. Pappalardi· 2 shared A. Arab· 1 shared A. J. Patel· 1 shared A. Navickas· 1 shared A. Y. Ge· 1 shared C. J. Lee· 1 shared C. R. Antonescu· 1 shared D. Li· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

M. B. Pappalardi

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2 papers

Recent·Most cited

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

A. Y. Ge, A. Arab, R. Dai, A. Navickas, L. Fish, K. Garcia, H. Asgharian, J. Goudreau, S. Lee, K. Keenan, M. B. Pappalardi, M. T. McCabe, L. Przybyla, H. Goodarzi, L. Gilbert

This study identifies RNA dynamics as key regulators of cellular response to decitabine in AML cells using a multiomics and CRISPR approach.

Scientific Reports · Oct 29, 2024Peer-reviewedCancer Biology

PRC2 Inactivating Mutations in Cancer are Synthetic Lethal with DNMT1 Targeted Therapy via Enhanced Viral Mimicry

A. J. Patel, S. Warda, J. L. V. Maag, R. Misra, M. A. Miranda-Roman, M. R. Pachai, C. J. Lee, D. Li, N. Wang, G. Bayshtok, Y. Meng, E. W. P. Wong, J. Yan, E. Giff, M. B. Pappalardi, , P. Chi

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

bioRxiv · May 28, 2022 · PreprintCancer Biology