Author

R. Misra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

C. J. Lee· 2 shared D. Zheng· 2 shared E. W. P. Wong· 2 shared P. Chi· 2 shared Y. Chen· 2 shared A. Hall· 1 shared A. Haller· 1 shared A. J. Patel· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

C. J. Lee

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

E. W. P. Wong, M. Sahin, R. Yang, U. Lee, Y. A. Zhan, R. Misra, F. Tomas, N. Alomran, A. Polyzos, C. J. Lee, T. Trieu, A. M. Fundichely, T. Wiesner, A. Rosowicz, S. Cheng, , P. Chi

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

bioRxiv · May 31, 2024 · PreprintCancer Biology

PRC2 Inactivating Mutations in Cancer are Synthetic Lethal with DNMT1 Targeted Therapy via Enhanced Viral Mimicry

A. J. Patel, S. Warda, J. L. V. Maag, R. Misra, M. A. Miranda-Roman, M. R. Pachai, C. J. Lee, D. Li, N. Wang, G. Bayshtok, Y. Meng, E. W. P. Wong, J. Yan, E. Giff, M. B. Pappalardi, , P. Chi

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

bioRxiv · May 28, 2022 · PreprintCancer Biology

Air pollution induces Staphylococcus aureus USA300 respiratory tract colonisation mediated by specific bacterial genetic responses dependent on the global virulence gene regulators Agr and Sae

J. Purves, S. J. K. Hussey, L. Corscadden, L. Purser, A. Hall, R. Misra, P. S. Monks, J. M. Ketley, P. W. Andrew, J. A. Morrissey

This study shows that exposure to black carbon increases Staphylococcus aureus virulence and colonization by altering gene expression, independent of host factors.

bioRxiv · Feb 4, 2022 · PreprintMicrobiology

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

M. Sugiyama, H. Cui, D. S. Redka, M. Karimzadeh, E. Rujas, H. Maan, S. Hayat, K. Cheung, R. Misra, J. B. McPhee, R. D. Viirre, A. Haller, R. Botelho, R. Karshafian, S. A. Sabatinos, , C. N. Antonescu

bioRxiv · Apr 13, 2021Cell Biology

Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in Escherichia coli

H. Gerken, P. Vuong, K. Soparkar, R. Misra

This study shows that the EnvZ/OmpR system and porins enhance ferrous iron uptake in E. coli, overcoming Fur repression and resolving a paradox in iron regulon expression.

bioRxiv · May 11, 2020Microbiology