Endosomal cAMP production broadly impacts the cellular phosphoproteome
N. G. Tsvetanova, M. Trester-Zedlitz, B. W. Newton, G. E. Peng, J. R. Johnson, D. Jimenez-Morales, A. P. Kurland, N. J. Krogan, M. von Zastrow
The paper shows that endosomal cAMP production leads to distinct phosphoproteomic changes compared to plasma membrane cAMP, with a strong bias toward dephosphorylation by PP2A-B56{delta}.
bioRxiv · Jan 6, 2021Cell Biology