Author

B. W. Newton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

J. R. Johnson· 4 shared N. J. Krogan· 4 shared E. Verschueren· 3 shared D. Jimenez-Morales· 2 shared A. D. Frankel· 1 shared A. J. Sabnis· 1 shared A. Marson· 1 shared A. P. Kurland· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersMicrobiology

J. R. Johnson

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Author profile →

4 papers

Recent·Most cited

Endosomal cAMP production broadly impacts the cellular phosphoproteome

N. G. Tsvetanova, M. Trester-Zedlitz, B. W. Newton, G. E. Peng, J. R. Johnson, D. Jimenez-Morales, A. P. Kurland, N. J. Krogan, M. von Zastrow

The paper shows that endosomal cAMP production leads to distinct phosphoproteomic changes compared to plasma membrane cAMP, with a strong bias toward dephosphorylation by PP2A-B56{delta}.

bioRxiv · Jan 6, 2021Cell Biology

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

J. R. Johnson, T. Parry, T. Repasy, K. M. Geiger, E. Verschueren, J. M. Budzik, D. Jimenez-Morales, B. W. Newton, E. Powell, L. Coscoy, D. A. Portnoy, N. J. Krogan, J. S. Cox

This study uses proteomics to analyze post-translational modifications in macrophages infected with three intracellular pathogens, revealing pathogen-specific molecular responses and a novel mechanism of virus-bacterial synergy.

bioRxiv · May 27, 2020 · PreprintMicrobiology

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

J. R. Johnson, D. C. Crosby, J. F. Hultquist, D. Li, J. Marlett, J. Swann, R. Hüttenhain, E. Verschueren, T. L. Johnson, B. W. Newton, M. Shales, P. Beltrao, A. D. Frankel, A. Marson, O. I. Fregoso, , N. J. Krogan

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

bioRxiv · Jan 6, 2020Microbiology

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

N. Chatterjee, E. Pazarentzos, G. Hrustanovic, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, V. Olivas, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, , T. G. Bivona

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

bioRxiv · Oct 11, 2018Cancer Biology