D. Jimenez-Morales

Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila

This study identifies how Legionella pneumophila modifies host ubiquitination during infection, revealing widespread monoubiquitination of small GTPases and the role of SidC/SdcA effectors.

Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection

This study shows that type I IFN promotes the maturation of inflammatory monocytes into pathogenic FasL+MCs during H5N1 infection, contributing to disease severity.

Endosomal cAMP production broadly impacts the cellular phosphoproteome

The paper shows that endosomal cAMP production leads to distinct phosphoproteomic changes compared to plasma membrane cAMP, with a strong bias toward dephosphorylation by PP2A-B56{delta}.

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

Ceragenins and antimicrobial peptides kill bacteria through distinct mechanisms

This study compares the mechanisms of action of cationic antimicrobial peptides and ceragenins, finding distinct bacterial responses despite some overlapping effects.

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

This study uses proteomics to analyze post-translational modifications in macrophages infected with three intracellular pathogens, revealing pathogen-specific molecular responses and a novel mechanism of virus-bacterial synergy.

Dynamic proteomics profiling of Legionella pneumophila infection unveils modulation of the host mitochondrial stress response pathway

This study profiles host cell proteome, ubiquitinome, and phosphoproteome during Legionella pneumophila infection, revealing modulation of mitochondrial stress response pathways.

Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation

The paper identifies NOSEMPE in brown adipocytes as a cause of mitochondrial ETC imbalance and shows it drives nonmitochondrial thermogenesis and metabolic improvement via ATF4 activation.

The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein

This study shows that ZIKV infection disrupts the NMD pathway by interacting with UPF1 via its capsid protein, enhancing viral infection and contributing to neuropathology.