The Arp1/11 Minifilament of Dynactin Primes the Endosomal Arp2/3 Complex
A. I. Fokin, V. David, K. Oguievetskaia, E. Derivery, C. E. Stone, L. Cao, N. Rocques, N. Molinie, V. Henriot, M. Aumont-Nicaise, M. V. Hinckelmann, F. SAUDOU, C. Le Clainche, A. P. Carter, G. Romet-Lemonne, A. M. Gautreau
The paper shows that the WASH complex interacts with Dynactin and uncaps it, allowing the Arp1/11 minifilament to prime Arp2/3 complex-mediated actin branching at endosomes.
bioRxiv · May 29, 2020Cell Biology