Author

C. Le Clainche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 7 Approach:experimental assay· 7 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Pernier· 4 shared A. M. Gautreau· 3 shared H. Wang· 3 shared A. I. Fokin· 2 shared H. Narassimprakash· 2 shared R. Said· 2 shared S. Romero· 2 shared V. Henriot· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiochemistry

J. Pernier

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Vinculin-Arp2/3 Interaction Inhibits Branched Actin Assembly to Control Cell Migration and Cell Cycle Progression

J. James, A. I. Fokin, D. Y. Guschin, H. Wang, A. Polesskaya, S. N. Rubtsova, C. Le Clainche, P. Silberzan, A. M. Gautreau, S. Romero

This study shows that vinculin's interaction with Arp2/3 inhibits branched actin assembly, affecting cell migration and cell cycle progression in mammary epithelial cells.

bioRxiv · Oct 9, 2023 · PreprintCell Biology

The adherens junction proteins α-catenin, vinculin and VASP cooperate to promote actin assembly

R. Said, H. Wang, J. Pernier, H. Narassimprakash, S. Romero, A. M. Gautreau, R.-M. Mege, C. Le Clainche

This study investigates how α-catenin, vinculin, and VASP work together in a complex to regulate actin assembly during adherens junction formation.

bioRxiv · Dec 4, 2022 · PreprintBiochemistry

Talin and vinculin combine their activities to trigger actin assembly

H. Wang, C. Vigouroux, R. Said, V. Henriot, J. Pernier, C. Le Clainche

This study shows that talin and vinculin work together to enhance actin assembly through a sequential mechanism involving nucleation, capping, and elongation.

bioRxiv · Dec 1, 2022Biochemistry

Shigella ipaA mediates actin bundling through diffusible vinculin oligomers with activation imprint

C. M. Valencia-Gallardo, D. I. Aguilar, H. Khakzad, B. Cocom-Chan, C. Bou-Nader, C. Velours, Y. Zarrouk, C. Le Clainche, C. Malosse, D. Borges-Lima, N. Quenech'Du, B. Mazhar, S. Essid, M. Fontecave, A. Asnacios, , G. Tran Van Nhieu

This study shows that Shigella IpaA induces vinculin homo-oligomerization, leading to actin bundling and stable cell adhesion independent of force transduction.

bioRxiv · Nov 7, 2022 · PreprintMicrobiology

Talin and kindlin cooperate to control the density of integrin clusters.

J. Pernier, M. Cardoso Dos Santos, M. Souissi, A. Joly, H. Narassimprakash, O. Rossier, G. Giannone, E. Helfer, K. Sengupta, C. Le Clainche

This study shows that talin and kindlin work together to control integrin cluster density, with kindlin enhancing talin and integrin density and facilitating cluster segregation by actomyosin.

bioRxiv · Oct 7, 2022 · PreprintBiochemistry

Activated I-BAR IRSp53 clustering controls the formation of VASP-actin-based membrane protrusions

F.-C. Tsai, J. M. Henderson, Z. Jarin, E. Kremneva, Y. Senju, J. Pernier, O. Mikhajlov, J. Manzi, K. Kogan, C. Le Clainche, G. A. Voth, P. Lappalainen, P. Bassereau

The paper investigates how IRSp53 clustering regulates filopodia initiation by recruiting VASP to form actin-based membrane protrusions.

bioRxiv · Mar 4, 2022Biophysics

The Arp1/11 Minifilament of Dynactin Primes the Endosomal Arp2/3 Complex

A. I. Fokin, V. David, K. Oguievetskaia, E. Derivery, C. E. Stone, L. Cao, N. Rocques, N. Molinie, V. Henriot, M. Aumont-Nicaise, M. V. Hinckelmann, F. SAUDOU, C. Le Clainche, A. P. Carter, G. Romet-Lemonne, A. M. Gautreau

The paper shows that the WASH complex interacts with Dynactin and uncaps it, allowing the Arp1/11 minifilament to prime Arp2/3 complex-mediated actin branching at endosomes.

bioRxiv · May 29, 2020Cell Biology