Author

A. I. Fokin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Organism:human· 2 Research Focus:clustering· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

A. M. Gautreau· 4 shared A. Polesskaya· 2 shared C. Le Clainche· 2 shared G. Simanov· 2 shared J. James· 2 shared K. Oguievetskaia· 2 shared A. Boutillon· 1 shared A. P. Carter· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

A. M. Gautreau

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4 papers

Recent·Most cited

Vinculin-Arp2/3 Interaction Inhibits Branched Actin Assembly to Control Cell Migration and Cell Cycle Progression

J. James, A. I. Fokin, D. Y. Guschin, H. Wang, A. Polesskaya, S. N. Rubtsova, C. Le Clainche, P. Silberzan, A. M. Gautreau, S. Romero

This study shows that vinculin's interaction with Arp2/3 inhibits branched actin assembly, affecting cell migration and cell cycle progression in mammary epithelial cells.

bioRxiv · Oct 9, 2023 · PreprintCell Biology

Inactivating Negative Regulators of Cortical Branched Actin Enhances Persistence of Single Cell Migration

A. I. Fokin, A. Boutillon, J. James, L. Courtois, S. Vacher, G. Simanov, Y. Wang, A. Polesskaya, I. Bieche, N. B. David, A. M. Gautreau

The paper shows that inactivating three negative regulators of cortical branched actin enhances migration persistence in human and zebrafish cells, with vimentin down-regulation contributing to the stable maintenance of this phenotype.

bioRxiv · May 13, 2023Cell Biology

Arpin regulates migration persistence by interacting with both tankyrases and the Arp2/3 complex

G. Simanov, I. Dang, A. I. Fokin, K. Oguievetskaia, V. Campanacci, J. Cherfils, A. M. Gautreau

This study identifies Arpin's interacting partners, showing it regulates migration persistence through two independent pathways involving Tankyrase and Arp2/3.

bioRxiv · Mar 16, 2021Cell Biology

The Arp1/11 Minifilament of Dynactin Primes the Endosomal Arp2/3 Complex

A. I. Fokin, V. David, K. Oguievetskaia, E. Derivery, C. E. Stone, L. Cao, N. Rocques, N. Molinie, V. Henriot, M. Aumont-Nicaise, M. V. Hinckelmann, F. SAUDOU, C. Le Clainche, A. P. Carter, G. Romet-Lemonne, A. M. Gautreau

The paper shows that the WASH complex interacts with Dynactin and uncaps it, allowing the Arp1/11 minifilament to prime Arp2/3 complex-mediated actin branching at endosomes.

bioRxiv · May 29, 2020Cell Biology