TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade
Y. Xiong, J. Sharma, M. N. Young, W. Xiong, A. Jazayeri, K. F. Poncha, M. X. Ilagan, Q. Wang, H. Zheng, N. L. Young, M. Sardiello
This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.
bioRxiv · Oct 16, 2023Cell Biology