Author

K. F. Poncha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

N. L. Young· 3 shared B. D. Strahl· 2 shared G. C. Fox· 2 shared K. Jain· 2 shared A. Jazayeri· 1 shared A. Vaidya· 1 shared B. C. Taylor· 1 shared B. Graham· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

N. L. Young

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Author profile →

3 papers

Recent·Most cited

H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

G. C. Fox, K. F. Poncha, B. R. Smith, L. N. van der Maas, N. N. Robbins, B. Graham, J. M. Dowen, B. D. Strahl, N. L. Young, K. Jain

The paper shows that H3K18 and H3K23 acetylation enhance MLL1-mediated H3K4 methylation, while other modifications are less affected by tail acetylation.

bioRxiv · May 13, 2024 · PreprintBiochemistry

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

Y. Xiong, J. Sharma, M. N. Young, W. Xiong, A. Jazayeri, K. F. Poncha, M. X. Ilagan, Q. Wang, H. Zheng, N. L. Young, M. Sardiello

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

bioRxiv · Oct 16, 2023Cell Biology

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

K. Jain, M. R. Marunde, J. M. Burg, S. L. Gloor, F. M. Joseph, K. F. Poncha, Z. B. Gillespie, K. L. Rodriguez, I. K. Popova, N. W. Hall, A. Vaidya, S. A. Howard, H. F. Taylor, L. Mukhsinova, U. C. Onuoha, , B. D. Strahl

The paper shows that H3 tail acetylation enhances accessibility of both H3K4 methyl readers and writers, revealing an acetylation-mediated chromatin switch that modulates H3K4 methylation read-write capability.

bioRxiv · Feb 28, 2022Biochemistry