A multiprotein signaling complex sustains AKT and mTOR/S6K activity necessary for the survival of cancer cells undergoing stress
O. Y. Teran Pumar, M. R. Zanotelli, M.-c. J. Lin, R. R. Schmitt, K. S. Green, K. S. Rojas, I. Y. Hwang, R. A. Cerione, K. F. Wilson
This study identifies a multiprotein complex, DockTOR, that sustains AKT and mTOR/S6K activity in cancer cells under stress, enabling survival through a mechanism independent of growth factor signaling.
bioRxiv · Jan 3, 2023 · PreprintCancer Biology