Author

M.-P. Chien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:fluorescence / live-cell microscopy· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Beerens· 4 shared L. You· 3 shared D. Brinks· 2 shared K. J. Feller· 2 shared P.-R. Su· 2 shared T.-C. Chou· 2 shared A. Biswas· 1 shared A. C. O'Farrell· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBioengineering

C. Beerens

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Plasmonic Enhancement of Protein Function

M. Locarno, Q. Dong, X. Meng, C. Glessi, N. Hettema, N. Brandsma, S. Blokhuizen, A. Castaneda, S. Ganapathy, M. Post, T. Schmidt, L. van Roemburg, B. Xu, C.-T. Cho, L. Laan, , D. Brinks

This study demonstrates plasmonic enhancement of protein function in living cells by coupling designed nanoparticles to Archaerhodopsin proteins, increasing fluorescence and response speed.

bioRxiv · Feb 7, 2024 · PreprintBiophysics

Identification of inter- and intra-tumoral molecular phenotypes steering temozolomide resistance in patient-derived glioblastoma cells.

F. Fabro, T. V. Kers, K. J. Feller, C. Beerens, I. Ntafoulis, A. Idbaih, M. Verrault, K. Connor, A. Biswas, M. Salvucci, J. H. M. Prehn, A. T. Byrne, A. C. O'Farrell, D. Lambrechts, G. Dilcan, , S. Leenstra

This study identifies two molecular phenotypes, ADA and N-ADA, associated with temozolomide resistance in glioblastoma cells through bulk and single-cell RNA sequencing.

bioRxiv · Aug 11, 2023Cancer Biology

Fast and Accurate Cell Tracking: a real-time cell segmentation and tracking algorithm to instantly export quantifiable cellular characteristics from large scale image data

T.-C. Chou, L. You, C. Beerens, K. J. Feller, M.-P. Chien

The paper introduces a real-time cell tracking algorithm, FACT, that rapidly segments and tracks cells in large image datasets with high precision and speed.

bioRxiv · Jan 9, 2023 · PreprintBioengineering

Functional single cell proteomic profiling of cells with abnormal DNA damage response dynamics

P.-R. Su, L. You, C. Beerens, K. Bezstarosti, J. Demmers, M. Pabst, R. Kanaar, C.-C. Hsu, M.-P. Chien

The paper develops FUNpro, a functional single-cell proteomic profiling method, to link proteomes with dynamic cellular phenotypes, identifying PDS5A and PGAM5 in DDR survival.

bioRxiv · Oct 13, 2021 · PreprintBioengineering

Functional single cell selection and annotated profiling of dynamically changing cancer cells

L. You, P.-R. Su, M. Betjes, R. Ghadiri Rad, T.-C. Chou, C. Beerens, E. van Oosten, F. Leufkens, P. Gasecka, M. Muraro, R. van Tol, D. van Steenderen, S. Farooq, J. Hardillo, R. Baatenburg de Jong, , M.-P. Chien

The paper introduces fSCS, a method to select and profile functionally dynamic cancer cells, revealing genes and pathways driving aggressive migration and mesenchymal morphology.

bioRxiv · Oct 12, 2021 · PreprintBioengineering