L. You

Follow-up availability and the robustness of immune transcriptomic recovery after myocardial infarction

The paper assesses the robustness of immune transcriptomic recovery after myocardial infarction by evaluating how missing data and assay availability affect inflammatory-response scores over time.

An engineered prodrug selectively suppresses β-lactam resistant bacteria in a mixed microbial setting

This paper engineers a prodrug that selectively suppresses β-lactam-resistant bacteria in mixed cultures by exploiting ESBL activity.

Circular RNA Obelisk-S.s is highly abundant in Streptococcus sanguinis SK36

The paper identifies a highly abundant circular RNA, Obelisk-S.s, in Streptococcus sanguinis SK36, despite its absence from the genome, and reports mutations in some samples.

Global control of cellular physiology by biomolecular condensates through modulation of electrochemical equilibria

This study shows that biomolecular condensates modulate electrochemical gradients in cells, affecting gene expression, membrane potential, and bacterial survival under antibiotic stress.

Fast and Accurate Cell Tracking: a real-time cell segmentation and tracking algorithm to instantly export quantifiable cellular characteristics from large scale image data

The paper introduces a real-time cell tracking algorithm, FACT, that rapidly segments and tracks cells in large image datasets with high precision and speed.

Mapping single-cell responses to population-level dynamics during antibiotic treatment

The paper maps single-cell lysis probabilities to population-level biomass dynamics during antibiotic treatment, showing how filamentation extent influences lysis and validates this with experiments.

A SI3-sigma; arch stabilizes cyanobacteria transcription initiation complex

The paper reports cryo-EM structures of cyanobacterial transcription initiation complexes and identifies an SI3-{sigma} arch that stabilizes the RNAP-promoter DNA open complex, essential for transcription initiation.

Functional single cell proteomic profiling of cells with abnormal DNA damage response dynamics

The paper develops FUNpro, a functional single-cell proteomic profiling method, to link proteomes with dynamic cellular phenotypes, identifying PDS5A and PGAM5 in DDR survival.

Functional single cell selection and annotated profiling of dynamically changing cancer cells

The paper introduces fSCS, a method to select and profile functionally dynamic cancer cells, revealing genes and pathways driving aggressive migration and mesenchymal morphology.

A quantitative approach to easily characterize and predict cell death and escape to β-lactam treatments

The paper develops a mathematical model to predict bacterial response to β-lactam antibiotics by integrating cellular heterogeneity and filamentation, showing it can reconcile growth and CFU data for ESBL-producing E. coli.

Heterogeneous timing of asexual cycles in Plasmodium falciparum quantified by extended time-lapse microscopy

This study quantifies the heterogeneous timing of asexual cycles in Plasmodium falciparum using time-lapse microscopy and finds that unsynchronized cultures have a bimodal burst time distribution and that artificial synchronization does not fundamentally alter cycle dynamics.

The Persistence Potential of Mobile Genetic Elements

The paper introduces a computational framework to analyze mobile genetic element persistence in microbial communities and derives a metric to predict their abundance and persistence.

Quantifying E2F1 protein dynamics in single cells

This study quantifies E2F1 protein dynamics in single cells using fluorescent reporters, revealing cell cycle-dependent expression patterns and the impact of 3UTR sequences.

Arabidopsis PPC2 is crucial for growth at low CO2 by involvement in photorespiratory metabolism and integration of ABI5

This study shows that Arabidopsis PPC2 is essential for growth at low CO2 by linking photorespiratory metabolism with primary metabolism and ABA signaling.

Crl activates transcription by stabilizing the active conformation of the master stress factor σS

This study determines the structure of an E. coli transcription activation complex and shows that Crl stabilizes σS to activate transcription without DNA contact.

Towards multi-drug adaptive therapy

This paper introduces three novel concepts to aid in designing multi-drug adaptive therapies for cancer by analyzing tumor evolution dynamics and treatment strategies.

High-throughput isolation and culture of human gut bacteria with droplet microfluidics

The paper develops a droplet microfluidics platform to isolate and culture human gut bacteria, demonstrating its use in studying metabolic variation and growth kinetics.

Effects of Biogas Slurry on Fruit Economic Traits and Soil Nutrient of Camellia oleifera Abel

This study examines how biogas slurry affects soil nutrients and economic traits of Camellia oleifera fruits, finding that higher application rates improve soil fertility and fruit yield.

Universal antibiotic tolerance arising from antibiotic-triggered accumulation of redox metabolites

This study identifies a mechanism by which Pseudomonas aeruginosa develops antibiotic tolerance through antibiotic-induced accumulation of redox metabolites like pyocyanin.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.