Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1
C. Lindon, A. A. Abdelbaki, C. Ascanelli, C. Okoye, H. B. Akman, G. Janson, M.-w. Min, C. Marcozzi, A. Hagting, R. Grant, M. De Luca, I. A. Asteriti, G. Guarguaglini, A. Paiardini
This study redefines AURKA degron motifs, showing the N-terminal A-box functions as a D-box and the C-terminal D-box is not a degron but a structural motif essential for AURKA's active conformation.
bioRxiv · Jan 31, 2022Cell Biology