Author

G. Guarguaglini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Lindon· 3 shared A. Paiardini· 2 shared C. Ascanelli· 2 shared H. B. Akman· 2 shared R. Grant· 2 shared A. A. Abdelbaki· 1 shared A. Abdelbaki· 1 shared A. De Leo· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

C. Lindon

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Author profile →

3 papers

Recent·Most cited

Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1

C. Lindon, A. A. Abdelbaki, C. Ascanelli, C. Okoye, H. B. Akman, G. Janson, M.-w. Min, C. Marcozzi, A. Hagting, R. Grant, M. De Luca, I. A. Asteriti, G. Guarguaglini, A. Paiardini

This study redefines AURKA degron motifs, showing the N-terminal A-box functions as a D-box and the C-terminal D-box is not a degron but a structural motif essential for AURKA's active conformation.

bioRxiv · Jan 31, 2022Cell Biology

A Focused Small-Molecule Screen Identifies PHA-680626 as an Amphosteric Inhibitor Disrupting the Interaction between Aurora-A and N-Myc

F. Souvalidou, D. Boi, R. Montanari, F. Polverino, G. Marini, D. Capelli, G. Pochetti, R. Contestabile, D. Trisciuoglio, A. Tramonti, P. Carpinelli, C. Ascanelli, C. Lindon, A. De Leo, R. Di Santo, , A. Paiardini

This study identifies PHA-680626 as an amphosteric inhibitor that disrupts the AURKA/N-Myc interaction, reducing N-Myc levels and cell viability in neuroblastoma cells.

bioRxiv · Mar 10, 2021 · PreprintCancer Biology

AURKA destruction is decoupled from its activity at mitotic exit but suppresses interphase activity

A. Abdelbaki, H. B. Akman, M. Poteau, R. Grant, G. Guarguaglini, o. C. G. Gavet, C. Lindon

The paper investigates AURKA activity regulation, finding that its inactivation at mitotic exit depends on TPX2 degradation, not AURKA destruction, and that FZR1 suppresses interphase AURKA activity.

bioRxiv · Nov 21, 2019Cell Biology