Author

C. Okoye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

C. Lindon· 2 shared A. A. Abdelbaki· 1 shared A. Hagting· 1 shared A. Paiardini· 1 shared C. Ascanelli· 1 shared C. Marcozzi· 1 shared C. Phillips· 1 shared C. Stubbs· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

C. Lindon

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2 papers

Recent·Most cited

Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

R. Eapen, C. Okoye, C. Stubbs, M. Schimpl, T. Tischer, E. J. Fisher, M. Zacharopoulou, F. Ferrer, D. Barford, D. Spring, C. Lindon, C. Phillips, L. S. Itzhaki

This study develops D-box peptides that inhibit APC/C by binding Cdc20, showing they are more potent than Apcin and can drive protein degradation.

bioRxiv · Apr 30, 2024Biochemistry

Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1

C. Lindon, A. A. Abdelbaki, C. Ascanelli, C. Okoye, H. B. Akman, G. Janson, M.-w. Min, C. Marcozzi, A. Hagting, R. Grant, M. De Luca, I. A. Asteriti, G. Guarguaglini, A. Paiardini

This study redefines AURKA degron motifs, showing the N-terminal A-box functions as a D-box and the C-terminal D-box is not a degron but a structural motif essential for AURKA's active conformation.

bioRxiv · Jan 31, 2022Cell Biology