YAP disrupts bile acid homeostasis to drive cancer-associated cachexia
Madeline Webb, Mikaela Wong, Anthony P. Karamalakis, Yuchen Liu, Kimberley Jane Evason, Kira Sun, Kristin Brown, Jay R. Black, Yingzi Yang, Andrew Graham Cox
This study identifies YAP's role in disrupting bile acid homeostasis to drive cachexia in zebrafish, showing that promoting bile acid excretion can alleviate the syndrome.
bioRxiv · Feb 3, 2026 · PreprintCancer Biology