Kimberley Jane Evason

Multi-Modal Kinome Profiling Discovers Mesenchymal-Like Polarity Networks that Underly Directed Hepatocellular Carcinoma Cell Migration

This study identifies a kinase network and DAPK3-driven polarity complex that promotes HCC cell migration and metastasis using a multi-modal profiling approach.

NRF2 co-opts the SWI/SNF complex to drive liver cell plasticity

This study shows NRF2 drives liver cell plasticity by co-opting the SWI/SNF complex, and identifies FHD-286 as a therapeutic inhibitor of this process.

Excessive Ca2+-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

YAP disrupts bile acid homeostasis to drive cancer-associated cachexia

This study identifies YAP's role in disrupting bile acid homeostasis to drive cachexia in zebrafish, showing that promoting bile acid excretion can alleviate the syndrome.

microRNA-21 promotes dysregulated lipid metabolism and hepatocellular carcinoma

This study identifies miR-21 as a dysregulated microRNA in MASH-HCC, showing it promotes lipid metabolic changes that contribute to hepatocarcinogenesis in zebrafish models.

Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

Long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin trafficking and secretion in mice

Genetic compensation in podocalyxin-like mutants during zebrafish liver development

This study investigates the role of podxl in zebrafish liver development and finds that its loss leads to reduced HSC numbers, with compensation through upregulation of extracellular matrix genes.

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.

Oct4 redox sensitivity potentiates reprogramming and differentiation

This study identifies a redox-sensitive cysteine residue in Oct4 that regulates reprogramming and differentiation by affecting DNA binding and ubiquitylation.

A novel missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish

This study identifies a missense mutation in the furinb gene in zebrafish that causes hepatic cysts by disrupting ER homeostasis and mTOR signaling during liver development.