Andrew Graham Cox

This study shows NRF2 drives liver cell plasticity by co-opting the SWI/SNF complex, and identifies FHD-286 as a therapeutic inhibitor of this process.

The paper shows that iron availability affects hepatocyte identity in HepG2 cells by modulating HNF4A-driven transcription.

This study shows that cholesterol biosynthesis is critical for myofibroblastic CAFs to remodel the extracellular matrix and promote tumor metastasis.

This study identifies YAP's role in disrupting bile acid homeostasis to drive cachexia in zebrafish, showing that promoting bile acid excretion can alleviate the syndrome.

This paper describes a cryoinjury model in zebrafish to study liver regeneration by inducing localized necrosis, inflammation, and fibrosis.

This paper develops a hepatic cryoinjury model to study liver regeneration and fibrosis, showing it enables comparison of healthy and injured tissue in the same animal.

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.