A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
Jesse D. Riordan, Teagan A. Nathanson, Afshin Varzavand, Adeline A. Hawkins, Rebekah M. Peplinski, Elizabeth C. Hannan, Faith A. Bibeau, Nathaniel J. Freesmeier, Madison C. Jilek, Silvia Coma, Jonathan A. Pachter, Adam J. Dupuy, Christopher S. Stipp
This study identifies FAK signaling as a critical target for overcoming Rac1-driven MAPK resistance in melanoma and shows that combining RAF/MEK and FAK inhibitors is effective.
Oncogene · Oct 18, 2025Peer-reviewedCancer Biology