Author

Rebekah M. Peplinski

University of IowaORCID 0000-0003-0209-3151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam J. DupuyiD· 2 shared Elizabeth C. HannaniD· 2 shared Jesse D. RiordaniD· 2 shared Adeline A. Hawkins· 1 shared Afshin VarzavandiD· 1 shared Christopher S. StippiD· 1 shared Faith A. Bibeau· 1 shared Jacob L. Schillo· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Adam J. DupuyORCID

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2 papers

Recent·Most cited

Cancer BiologyGynecologic OncologyPeer-reviewedDec 5, 2025

Co-targeting the PI3K-Akt pathway improves response to MEK inhibition in low-grade serous ovarian cancer cell lines

Rebekah M. Peplinski, Jesse D. Riordan, Jacob L. Schillo…·Adam J. Dupuy

This study shows that combining MEK and PI3K-Akt inhibition enhances anti-tumor effects in LGSOC cells and may overcome resistance to MEK inhibitors.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyOncogenePeer-reviewedOct 18, 2025

A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition

Jesse D. Riordan, Teagan A. Nathanson, Afshin Varzavand…·Christopher S. Stipp

This study identifies FAK signaling as a critical target for overcoming Rac1-driven MAPK resistance in melanoma and shows that combining RAF/MEK and FAK inhibitors is effective.

7 citations

humanproteomics

𝕏 PostBluesky