Adam J. Dupuy

The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.

This study identifies genes driving resistance to FR900359 in uveal melanoma cells through functional genomics screening and experimental validation.

This study shows that Mitfa-independent melanocyte progenitors in zebrafish are more susceptible to GNAQ-induced uveal melanoma than differentiated melanocytes.

This study shows that combining MEK and PI3K-Akt inhibition enhances anti-tumor effects in LGSOC cells and may overcome resistance to MEK inhibitors.

This study identifies FAK signaling as a critical target for overcoming Rac1-driven MAPK resistance in melanoma and shows that combining RAF/MEK and FAK inhibitors is effective.

This paper introduces a simplified transposon mutagenesis method for phenotypic forward genetic screens in cultured cells, demonstrating high reproducibility across independent replicates.