Tumor Cell Death Drives Tumor-Promoting IL-6+ iCAF formation via P2X7-activation
Ciarán McDonnell, Valeriya V. Zinina, Amina Othman, Larissa Launhardt, Anna I. Brichkina, Fatma Aktuna, Magdalena Brkic, Matthias Lauth, Eliana Stanganello, Mark R. Schmitt
The paper shows chemotherapy-induced ATP release from dying pancreatic cancer cells activates P2X7 in stellate cells, promoting IL-6 production and tumor resistance.
bioRxiv · Mar 20, 2026 · PreprintCancer Biology