Author

Mark R. Schmitt

Philipps University of MarburgORCID 0000-0002-1493-1127Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1

Frequent Co-Authors

Fatma Aktuna· 2 shared Valeriya V. ZininaiD· 2 shared Amina Othman· 1 shared Andrea SacchettiiD· 1 shared Anna I. BrichkinaiD· 1 shared Ciarán McDonnelliD· 1 shared Coen Linn· 1 shared Eliana StanganelloiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Fatma Aktuna

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2 papers

Recent·Most cited

Western-style diet-induced microbial shifts and inflammation reprogram c-Kit⁺ secretory cells into targets for tumor initiation

Sara Silva, Paola Procopio, Valeriya V. Zinina, Solveig Turss, Rafael R. Segura Muñoz, Seyram Segbefia, Sena Bae, Lior Lobel, Luigi L. Nardella, Andrea Sacchetti, Rosalie Joosten, Coen Linn, Susanna Plugge, Mathijs P. Verhagen, Fatma Aktuna, , Mark R. Schmitt

This study shows that a Western-style diet reprograms c-Kit⁺ secretory cells into tumor-initiating cells via microbial shifts and inflammation.

bioRxiv · Jul 19, 2026 · PreprintCell Biology

Tumor Cell Death Drives Tumor-Promoting IL-6+ iCAF formation via P2X7-activation

Ciarán McDonnell, Valeriya V. Zinina, Amina Othman, Larissa Launhardt, Anna I. Brichkina, Fatma Aktuna, Magdalena Brkic, Matthias Lauth, Eliana Stanganello, Mark R. Schmitt

The paper shows chemotherapy-induced ATP release from dying pancreatic cancer cells activates P2X7 in stellate cells, promoting IL-6 production and tumor resistance.

bioRxiv · Mar 20, 2026 · PreprintCancer Biology