Human POMC processing in vitro and in vivo revealed by quantitative peptidomics
Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz‐Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne E. White, Fiona Mary Gribble, Frank M. Reimann, I. Sadaf Farooqi, Stephen O’Rahilly, Florian T. Merkle
The paper identifies β-MSH and desacetyl-MSH as major POMC-derived peptides in human hypothalamic neurons, suggesting their underappreciated role in obesity.
Molecular Metabolism · Aug 21, 2018Peer-reviewedNeuroscience