Peter Kirwan

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

The paper identifies β-MSH and desacetyl-MSH as major POMC-derived peptides in human hypothalamic neurons, suggesting their underappreciated role in obesity.

This study identifies novel Ca2+ signaling mechanisms by which hypothalamic neurons in mice and humans rapidly respond to L-leucine, showing both activation and inhibition of specific neuron types.