Fiona Mary Gribble

IFNα differentially disrupts stimulus-secretion coupling in pancreatic alpha and beta cells

This study shows that IFNα disrupts stimulus-secretion coupling in pancreatic alpha and beta cells, with cell-type specific effects on SERCA2 and mitochondrial respiration.

Opposing GIPR brainstem circuits differentially control feeding behaviour

The paper identifies opposing roles of GIPR neurons in the area postrema and nucleus tractus solitarius in controlling feeding behavior and satiation.

Functional segregation of body-brain signals in the area postrema

The paper identifies distinct AP neuron subtypes that respond to different macronutrients and physiological signals, revealing their roles in satiety and homeostasis beyond nausea.

Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice

This study shows that chronic activation of GLP-1 neurons in the brainstem reduces food intake and causes sustained weight loss in obese mice.

Non-canonical signaling mechanisms of short-chain fatty acid receptors in glucagon-like peptide-1 (GLP-1) releasing enteroendocrine cells

This study investigates how FFA2 and FFA3 activation in enteroendocrine cells affects GLP-1 secretion through non-canonical signaling pathways.

The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice

This study shows that exendin-4 improves bone strength in ovariectomized mice through a central mechanism, not directly on bone cells.

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis by enhancing GLP-1 secretion and L-cell differentiation

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

Intestinal enteroendocrine cell subtype differentiation and hormone production in zebrafish

The paper identifies EEC subtypes and hormone production in zebrafish using single-cell RNA sequencing and mass spectrometry, revealing distinct precursor relationships.

Mechanisms of Activation and Serotonin release from Human Enterochromaffin Cells

This study investigates mechanisms of serotonin release from human enterochromaffin cells using organoids and functional assays, identifying key receptors and signaling pathways involved.

Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss

GLP-1R agonists activate human hypothalamic neurons

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

Enteroendocrine cell lineages that differentially control feeding and gut motility

This study identifies the physiological roles of different enteroendocrine cell lineages in controlling feeding and gut motility using genetic and chemogenetic approaches.

Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

This study identifies brainstem GLP-1 neurons as essential for lorcaserin's effect on reducing food intake in mice and suggests combination therapy with GLP-1R agonists may enhance efficacy.

Central and peripheral GLP-1 systems independently and additively suppress eating

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

This study identifies genetic associations with metabolite levels across multiple cohorts and links these variants to clinical outcomes like type 2 diabetes and macular telangiectasia type 2.

Human POMC processing in vitro and in vivo revealed by quantitative peptidomics

The paper identifies β-MSH and desacetyl-MSH as major POMC-derived peptides in human hypothalamic neurons, suggesting their underappreciated role in obesity.

Rapid sensing of L-leucine by human and murine hypothalamic neurons: neurochemical and mechanistic insights

This study identifies novel Ca2+ signaling mechanisms by which hypothalamic neurons in mice and humans rapidly respond to L-leucine, showing both activation and inhibition of specific neuron types.