Author

Julie Jerber

Wellcome Sanger InstituteORCID 0000-0002-3382-0860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Florian T. MerkleiD· 2 shared Helena KilpineniD· 2 shared Pau PuigdevalliD· 2 shared Sergi CastellanoiD· 2 shared Alessandro Di Domenico· 1 shared Anna S. E. CuomoiD· 1 shared Anne E. WhiteiD· 1 shared Bas BrouwersiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenetics

Florian T. MerkleORCID

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Author profile →

4 papers

Recent·Most cited

An in vivo and in vitro spatiotemporal atlas of human midbrain development

Dimitri Budinger, Pau Puigdevall, George T. Hall, Charlotte Roth, Theodoros A. Xenakis, Elena Marrosu, Julie Jerber, Alessandro Di Domenico, Francesca Picco, Helena Kilpinen, Sergi Castellano, Manju A. Kurian, Serena Barral

This study compares in vivo and in vitro midbrain development to assess their similarity to human fetal tissue.

Nature Communications · Feb 3, 2026Peer-reviewedNeuroscience

Effects of somatic mutations on cellular differentiation in iPSC models of neurodevelopment

Pau Puigdevall, Julie Jerber, Petr Danecek, Sergi Castellano, Helena Kilpinen

This study investigates how somatic mutations affect dopaminergic neuron differentiation in iPSCs, finding that deleterious mutations in key genes like BCOR are linked to differentiation failure and altered proliferation.

Cell Genomics · Mar 23, 2023Peer-reviewedGenomics

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation

Julie Jerber, Daniel D. Seaton, Anna S. E. Cuomo, Natsuhiko Kumasaka, James Haldane, Juliette Steer, Minal J Patel, Daniel Pearce, Malin H. L. Andersson, Marc Jan Bonder, Edward Mountjoy, Maya Ghoussaini, Madeline A. Lancaster, John C. Marioni, Florian T. Merkle, , Oliver Stegle

The paper uses single-cell RNA sequencing to study genetic variant effects on dopaminergic neuron differentiation from iPSCs, identifying eQTL and cell fate markers.

Nature Genetics · Mar 1, 2021Peer-reviewedGenetics

Human POMC processing in vitro and in vivo revealed by quantitative peptidomics

Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz‐Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne E. White, Fiona Mary Gribble, Frank M. Reimann, I. Sadaf Farooqi, Stephen O’Rahilly, Florian T. Merkle

The paper identifies β-MSH and desacetyl-MSH as major POMC-derived peptides in human hypothalamic neurons, suggesting their underappreciated role in obesity.

Molecular Metabolism · Aug 21, 2018Peer-reviewedNeuroscience