Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade
Mehdi Chaib, Muhammad Aminu, Shelley M. Herbrich, Mahshid Arabi, Yue Xuan, Akshay Basi, Tod D. Casasent, Marc Daniel Macaluso, Kenneth H. Hu, Matthew M. Gubin, Xi Chen, James J. Mancuso, Sreyashi Basu, Sonali Jindal, Jared Burks, , Padmanee Sharma
The paper identifies tetrads as a multicellular immune unit that correlates with antitumor immunity and response to checkpoint blockade in mouse and human tumors.
bioRxiv · Dec 29, 2025 · PreprintImmunology