Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome
Emily McMahon, Sherihan El‐Sayed, Jack Green, Christopher Hoyle, Lorna M. FitzPatrick, Emma V. Jones, Eve Corrie, Rebecca L. Kelly, Mairi Challinor, Sally Freeman, Richard A. Bryce, Catherine B. Lawrence, David Brough, Paul R. Kasher
This study identifies brazilin as a natural product inhibitor of the NLRP3 inflammasome, effective in multiple models and suggesting its potential as a therapeutic scaffold.
iScience · Jan 21, 2024Peer-reviewedMolecular Biology