Paul R. Kasher

The paper systematically analyzes homozygous autosomal copy number losses in exomes to improve diagnostic yield and identify ultra-rare recessive disorders.

This study shows that vascular dilation reduces haematoma size in zebrafish ICH models, suggesting haemodynamic regulation influences haemorrhage progression.

The paper shows that 25-hydroxycholesterol disrupts brain endothelial function by altering cholesterol metabolism, linking viral infection to brain vessel dysfunction in intracerebral haemorrhage.

This study identifies brazilin as a natural product inhibitor of the NLRP3 inflammasome, effective in multiple models and suggesting its potential as a therapeutic scaffold.

The paper identifies a novel base-pairing interaction in the U8 snoRNA that underlies a Mendelian form of cerebral small vessel disease by analyzing zebrafish models and patient fibroblasts.