Christopher Hoyle

In vivo cellular localisation and nanoscale organisation of NLRP3 inflammasomes

This study uses reporter mice to visualise NLRP3 inflammasomes in vivo, revealing their localisation, organisation, and cellular sources.

Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1α

This study disrupts the nuclear localisation sequence of endogenous IL-1α in mice and examines its effects on inflammatory responses, finding no significant changes in LPS-induced transcriptional signatures or IL-1 release.

25-hydroxycholesterol promotes brain endothelial dysfunction by remodelling cholesterol metabolism

The paper shows that 25-hydroxycholesterol disrupts brain endothelial function by altering cholesterol metabolism, linking viral infection to brain vessel dysfunction in intracerebral haemorrhage.

Lysosome positioning affects NLRP3 inflammasome activation

This study investigates how lysosome positioning affects NLRP3 inflammasome activation in HeLa and macrophage cells, finding that peripheral lysosome positioning enhances inflammasome activation.

Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome

This study identifies brazilin as a natural product inhibitor of the NLRP3 inflammasome, effective in multiple models and suggesting its potential as a therapeutic scaffold.